Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1) and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 in mouse models of Alzheimer's disease have opposing effects on amyloid-β and tau pathologies raising concerns about...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Hickman, Suzanne E., Allison, Elizabeth K., Coleman, Uwanda, Kingery-Gallagher, Nathan D., El Khoury, Joseph
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900980/
https://ncbi.nlm.nih.gov/pubmed/31849963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02780
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