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Absence of CX3CR1 impairs the internalization of Tau by microglia
BACKGROUND: Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. METHODS: We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, a...
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| Publicado no: | Mol Neurodegener |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5558740/ https://ncbi.nlm.nih.gov/pubmed/28810892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0200-1 |
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