Absence of CX3CR1 impairs the internalization of Tau by microglia

BACKGROUND: Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. METHODS: We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, a...

Full description

Saved in:
Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Bolós, Marta, Llorens-Martín, María, Perea, Juan Ramón, Jurado-Arjona, Jerónimo, Rábano, Alberto, Hernández, Félix, Avila, Jesús
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558740/
https://ncbi.nlm.nih.gov/pubmed/28810892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0200-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items