Absence of CX3CR1 impairs the internalization of Tau by microglia

BACKGROUND: Extracellular Tau is toxic for neighboring cells, and it contributes to the progression of AD. The CX3CL1/CX3CR1 axis is an important neuron/microglia communication mechanism. METHODS: We studied Tau clearance by microglia both in vitro (microglia primary cultures treated with Cy5-Tau, a...

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Publicado en:Mol Neurodegener
Autores principales: Bolós, Marta, Llorens-Martín, María, Perea, Juan Ramón, Jurado-Arjona, Jerónimo, Rábano, Alberto, Hernández, Félix, Avila, Jesús
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558740/
https://ncbi.nlm.nih.gov/pubmed/28810892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0200-1
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