Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1) and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 in mouse models of Alzheimer's disease have opposing effects on amyloid-β and tau pathologies raising concerns about...

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Vydáno v:Front Immunol
Hlavní autoři: Hickman, Suzanne E., Allison, Elizabeth K., Coleman, Uwanda, Kingery-Gallagher, Nathan D., El Khoury, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900980/
https://ncbi.nlm.nih.gov/pubmed/31849963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02780
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