Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Dependence on the 26S proteasome is an Achilles’ heel for triple-negative breast cancer (TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib, successfully targets MM but often leads to drug-resistant disease relapse and fails in breast cancer. Here we show that a 26S pr...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Banerjee, Sourav, Wei, Tiantian, Wang, Jue, Lee, Jenna J., Gutierrez, Haydee L., Chapman, Owen, Wiley, Sandra E., Mayfield, Joshua E., Tandon, Vasudha, Juarez, Edwin F., Chavez, Lukas, Liang, Ruqi, Sah, Robert L., Costello, Caitlin, Mesirov, Jill P., de la Vega, Laureano, Cooper, Kimberly L., Dixon, Jack E., Xiao, Junyu, Lei, Xiaoguang
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900511/
https://ncbi.nlm.nih.gov/pubmed/31754034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912033116
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