Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8(+) T cells in HIV-1 infection

Peptides generated by proteasome-catalyzed splicing of noncontiguous amino acid sequences have been shown to constitute a source of nontemplated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8(+) T cells are key mediators of HIV typ...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Paes, Wayne, Leonov, German, Partridge, Thomas, Chikata, Takayuki, Murakoshi, Hayato, Frangou, Anna, Brackenridge, Simon, Nicastri, Annalisa, Smith, Andrew G., Learn, Gerald H., Li, Yingying, Parker, Robert, Oka, Shinichi, Pellegrino, Pierre, Williams, Ian, Haynes, Barton F., McMichael, Andrew J., Shaw, George M., Hahn, Beatrice H., Takiguchi, Masafumi, Ternette, Nicola, Borrow, Persephone
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900506/
https://ncbi.nlm.nih.gov/pubmed/31748275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911622116
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