C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon Hg(II) Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?

Intracellular Cu(I) is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that Hg(II) does not activate transcription, as bis‐thiolate metal sites exhibit high affinity for Hg(II). Here the binding of Hg(II)...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chemistry
Main Authors: Balogh, Ria K., Gyurcsik, Béla, Hunyadi‐Gulyás, Éva, Schell, Juliana, Thulstrup, Peter W., Hemmingsen, Lars, Jancsó, Attila
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899792/
https://ncbi.nlm.nih.gov/pubmed/31365771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902940
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