C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon Hg(II) Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?

Intracellular Cu(I) is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that Hg(II) does not activate transcription, as bis‐thiolate metal sites exhibit high affinity for Hg(II). Here the binding of Hg(II)...

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發表在:Chemistry
Main Authors: Balogh, Ria K., Gyurcsik, Béla, Hunyadi‐Gulyás, Éva, Schell, Juliana, Thulstrup, Peter W., Hemmingsen, Lars, Jancsó, Attila
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
主題:
Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899792/
https://ncbi.nlm.nih.gov/pubmed/31365771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902940
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