C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon Hg(II) Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?

Intracellular Cu(I) is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that Hg(II) does not activate transcription, as bis‐thiolate metal sites exhibit high affinity for Hg(II). Here the binding of Hg(II)...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Balogh, Ria K., Gyurcsik, Béla, Hunyadi‐Gulyás, Éva, Schell, Juliana, Thulstrup, Peter W., Hemmingsen, Lars, Jancsó, Attila
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899792/
https://ncbi.nlm.nih.gov/pubmed/31365771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902940
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