C‐terminal Cysteines of CueR Act as Auxiliary Metal Site Ligands upon Hg(II) Binding—A Mechanism To Prevent Transcriptional Activation by Divalent Metal Ions?

Intracellular Cu(I) is controlled by the transcriptional regulator CueR, which effectively discriminates between monovalent and divalent metal ions. It is intriguing that Hg(II) does not activate transcription, as bis‐thiolate metal sites exhibit high affinity for Hg(II). Here the binding of Hg(II)...

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Détails bibliographiques
Publié dans:Chemistry
Auteurs principaux: Balogh, Ria K., Gyurcsik, Béla, Hunyadi‐Gulyás, Éva, Schell, Juliana, Thulstrup, Peter W., Hemmingsen, Lars, Jancsó, Attila
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899792/
https://ncbi.nlm.nih.gov/pubmed/31365771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201902940
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