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Bioactivation mechanisms of N‐hydroxyaristolactams: Nitroreduction metabolites of aristolochic acids

Aristolochic acids (AAs) are human nephrotoxins and carcinogens found in concoctions of Aristolochia plants used in traditional medicinal practices worldwide. Genotoxicity of AAs is associated with the formation of active species catalyzed by metabolic enzymes, the full repertoire of which is unknow...

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Dettagli Bibliografici
Pubblicato in:Environ Mol Mutagen
Autori principali: Okuno, Yoshiharu, Bonala, Radha, Attaluri, Sivaprasad, Johnson, Francis, Grollman, Arthur P., Sidorenko, Viktoriya S., Oda, Yoshimitsu
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899766/
https://ncbi.nlm.nih.gov/pubmed/31374128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22321
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