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Detoxification of aristolochic acid I by O-demethylation: Less nephrotoxicity and genotoxicity of aristolochic acid la in rodents

Ingestion of aristolochic acids (AA) contained in herbal remedies results in aristolochic acid nephropathy (AAN), which is characterized by chronic renal failure, tubulointerstitial fibrosis and urothelial cancer. AA I and AA II, primary components in AA, have similar genotoxic potential, whereas on...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Shibutani, Shinya, Bonala, Radha R., Rosenquist, Thomas, Rieger, Robert, Suzuki, Naomi, Johnson, Francis, Miller, Frederick, Grollman, Arthur P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226239/
https://ncbi.nlm.nih.gov/pubmed/20039324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25141
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