Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns. Plant-derived aristolochic acids are among the most potent nephrotoxins and carcinogens discovered to date, yet the mechanism...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Chang, Shih-Yu, Weber, Elijah J., Sidorenko, Viktoriya S., Chapron, Alenka, Yeung, Catherine K., Gao, Chunying, Mao, Qingcheng, Shen, Danny, Wang, Joanne, Rosenquist, Thomas A., Dickman, Kathleen G., Neumann, Thomas, Grollman, Arthur P., Kelly, Edward J., Himmelfarb, Jonathan, Eaton, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752374/
https://ncbi.nlm.nih.gov/pubmed/29202460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95978
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