Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns. Plant-derived aristolochic acids are among the most potent nephrotoxins and carcinogens discovered to date, yet the mechanism...

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Pubblicato in:JCI Insight
Autori principali: Chang, Shih-Yu, Weber, Elijah J., Sidorenko, Viktoriya S., Chapron, Alenka, Yeung, Catherine K., Gao, Chunying, Mao, Qingcheng, Shen, Danny, Wang, Joanne, Rosenquist, Thomas A., Dickman, Kathleen G., Neumann, Thomas, Grollman, Arthur P., Kelly, Edward J., Himmelfarb, Jonathan, Eaton, David L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752374/
https://ncbi.nlm.nih.gov/pubmed/29202460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95978
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