Structure‐Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases

Human histone demethylases are known to play an important role in the development of several tumor types. Consequently, they have emerged as important medical targets for the treatment of human cancer. Herein, structural studies on tetrazolylhydrazide inhibitors as a new scaffold for a certain class...

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Publicado en:ChemMedChem
Main Authors: Małecki, Piotr H., Rüger, Nicole, Roatsch, Martin, Krylova, Oxana, Link, Andreas, Jung, Manfred, Heinemann, Udo, Weiss, Manfred S.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899576/
https://ncbi.nlm.nih.gov/pubmed/31475772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900441
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