Structure‐Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases

Human histone demethylases are known to play an important role in the development of several tumor types. Consequently, they have emerged as important medical targets for the treatment of human cancer. Herein, structural studies on tetrazolylhydrazide inhibitors as a new scaffold for a certain class...

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Vydáno v:ChemMedChem
Hlavní autoři: Małecki, Piotr H., Rüger, Nicole, Roatsch, Martin, Krylova, Oxana, Link, Andreas, Jung, Manfred, Heinemann, Udo, Weiss, Manfred S.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899576/
https://ncbi.nlm.nih.gov/pubmed/31475772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900441
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