Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization

Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. Here we show the identification of muscleblind as a novel modifier of FUS-mediated neur...

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Publicado no:Nat Commun
Main Authors: Casci, Ian, Krishnamurthy, Karthik, Kour, Sukhleen, Tripathy, Vadreenath, Ramesh, Nandini, Anderson, Eric N., Marrone, Lara, Grant, Rogan A., Oliver, Stacie, Gochenaur, Lauren, Patel, Krishani, Sterneckert, Jared, Gleixner, Amanda M., Donnelly, Christopher J., Ruepp, Marc-David, Sini, Antonella M., Zuccaro, Emanuela, Pennuto, Maria, Pasinelli, Piera, Pandey, Udai Bhan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898697/
https://ncbi.nlm.nih.gov/pubmed/31811140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13383-z
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