FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by motor neuron degeneration and associated with aggregation of nuclear RNA-binding proteins (RBPs), including FUS. How FUS aggregation and neurodegeneration are prevented in healthy motor neurons remain critically unanswered ques...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Marrone, Lara, Drexler, Hannes C. A., Wang, Jie, Tripathi, Priyanka, Distler, Tania, Heisterkamp, Patrick, Anderson, Eric Nathaniel, Kour, Sukhleen, Moraiti, Anastasia, Maharana, Shovamayee, Bhatnagar, Rajat, Belgard, T. Grant, Tripathy, Vadreenath, Kalmbach, Norman, Hosseinzadeh, Zohreh, Crippa, Valeria, Abo-Rady, Masin, Wegner, Florian, Poletti, Angelo, Troost, Dirk, Aronica, Eleonora, Busskamp, Volker, Weis, Joachim, Pandey, Udai Bhan, Hyman, Anthony A., Alberti, Simon, Goswami, Anand, Sterneckert, Jared
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570784/
https://ncbi.nlm.nih.gov/pubmed/30937520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01998-x
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