FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by motor neuron degeneration and associated with aggregation of nuclear RNA-binding proteins (RBPs), including FUS. How FUS aggregation and neurodegeneration are prevented in healthy motor neurons remain critically unanswered ques...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Acta Neuropathol
Main Authors: Marrone, Lara, Drexler, Hannes C. A., Wang, Jie, Tripathi, Priyanka, Distler, Tania, Heisterkamp, Patrick, Anderson, Eric Nathaniel, Kour, Sukhleen, Moraiti, Anastasia, Maharana, Shovamayee, Bhatnagar, Rajat, Belgard, T. Grant, Tripathy, Vadreenath, Kalmbach, Norman, Hosseinzadeh, Zohreh, Crippa, Valeria, Abo-Rady, Masin, Wegner, Florian, Poletti, Angelo, Troost, Dirk, Aronica, Eleonora, Busskamp, Volker, Weis, Joachim, Pandey, Udai Bhan, Hyman, Anthony A., Alberti, Simon, Goswami, Anand, Sterneckert, Jared
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer Berlin Heidelberg 2019
נושאים:
Original Paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570784/
https://ncbi.nlm.nih.gov/pubmed/30937520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01998-x
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