RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations

Amyotrophic lateral sclerosis (ALS) is an uncommon neurodegenerative disease caused by degeneration of upper and lower motor neurons. Several genes, including SOD1, TDP-43, FUS, Ubiquilin 2, C9orf72 and Profilin 1, have been linked with the sporadic and familiar forms of ALS. FUS is a DNA/RNA-bindin...

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Main Authors: Daigle, J. Gavin, Lanson, Nicholas A., Smith, Rebecca B., Casci, Ian, Maltare, Astha, Monaghan, John, Nichols, Charles D., Kryndushkin, Dmitri, Shewmaker, Frank, Pandey, Udai Bhan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578413/
https://ncbi.nlm.nih.gov/pubmed/23257289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds526
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