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Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm

Fused in sarcoma (FUS) belongs to the group of RNA-binding proteins implicated as underlying factors in amyotrophic lateral sclerosis (ALS) and certain other neurodegenerative diseases. Multiple FUS gene mutations have been linked to hereditary forms, and aggregation of FUS protein is believed to pl...

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Bibliografiske detaljer
Main Authors: Shelkovnikova, Tatyana A, Robinson, Hannah K, Connor-Robson, Natalie, Buchman, Vladimir L
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865015/
https://ncbi.nlm.nih.gov/pubmed/24013423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26241
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