Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads invariably to fatal paralysis associated with motor neuron degeneration and muscular atrophy. One gene associated with ALS encodes the DNA/RNA-binding protein Fused in Sarcoma (FUS). There now exist two Drosop...

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Main Authors: Shahidullah, Mohammad, Le Marchand, Sylvain J., Fei, Hong, Zhang, Jiaming, Pandey, Udai Bhan, Dalva, Matthew B., Pasinelli, Piera, Levitan, Irwin B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858628/
https://ncbi.nlm.nih.gov/pubmed/24336723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3396-13.2013
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