Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing

Efficient cytosolic protein delivery is necessary to fully realize the potential of protein therapeutics. Current methods of protein delivery often suffer from low serum tolerance and limited in vivo efficacy. Here, we report the synthesis and validation of a previously unreported class of carboxyla...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Adv
Egile Nagusiak: Rui, Yuan, Wilson, David R., Choi, John, Varanasi, Mahita, Sanders, Katie, Karlsson, Johan, Lim, Michael, Green, Jordan J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2019
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897553/
https://ncbi.nlm.nih.gov/pubmed/31840076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay3255
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