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Efficiency of Cytosolic Delivery with Poly(beta-amino ester) Nanoparticles is Dependent on the Effective pKa of the Polymer
The mechanism by which cationic polymers containing titratable amines mediate effective endosomal escape and cytosolic delivery of nucleic acids is not well understood despite the decades of research devoted to these materials. Here we utilize multiple assays investigating the endosomal escape step...
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| Pubblicato in: | ACS Biomater Sci Eng |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8034557/ https://ncbi.nlm.nih.gov/pubmed/33463158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.0c00271 |
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