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Efficiency of Cytosolic Delivery with Poly(beta-amino ester) Nanoparticles is Dependent on the Effective pKa of the Polymer

The mechanism by which cationic polymers containing titratable amines mediate effective endosomal escape and cytosolic delivery of nucleic acids is not well understood despite the decades of research devoted to these materials. Here we utilize multiple assays investigating the endosomal escape step...

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Detalhes bibliográficos
Publicado no:ACS Biomater Sci Eng
Main Authors: Routkevitch, Denis, Sudhakar, Deepti, Conge, Marranne, Varanasi, Mahita, Tzeng, Stephany Y., Wilson, David R., Green, Jordan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034557/
https://ncbi.nlm.nih.gov/pubmed/33463158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.0c00271
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