C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer’s disease

According to the amyloid hypothesis of Alzheimer’s disease (AD) the deposition of prefibrillar and fibrillar Aβ peptide sets off the pathogenic cascades of neuroinflammation and neurodegeneration that lead to synaptic and neuronal loss resulting in cognitive decline. Various approaches to reduce amy...

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Vydáno v:PLoS One
Hlavní autoři: Panayiotou, Elena, Fella, Eleni, Andreou, Savanna, Papacharalambous, Revekka, Gerasimou, Petroula, Costeas, Paul, Angeli, Stella, Kousiappa, Ioanna, Papacostas, Savvas, Kyriakides, Theodoros
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897413/
https://ncbi.nlm.nih.gov/pubmed/31809505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225417
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