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C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy

ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Panayiotou, Elena, Fella, Eleni, Papacharalambous, Revekka, Malas, Stavros, Saraiva, Maria Joao, Kyriakides, Theodoros
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391113/
https://ncbi.nlm.nih.gov/pubmed/28407005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175767
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