Genetic background modifies amyloidosis in a mouse model of ATTR neuropathy

Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice bearing the same...

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Publicado en:Biochem Biophys Rep
Autores principales: Panayiotou, E., Papacharalambous, R., Antoniou, A., Christophides, G., Papageorgiou, L., Fella, E., Malas, S., Kyriakides, T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613746/
https://ncbi.nlm.nih.gov/pubmed/28955941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.08.005
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