Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, altered APP processing itself disrupts axonal transport. The mecha...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Mórotz, Gábor M., Glennon, Elizabeth B., Greig, Jenny, Lau, Dawn H. W., Bhembre, Nishita, Mattedi, Francesca, Muschalik, Nadine, Noble, Wendy, Vagnoni, Alessio, Miller, Christopher C. J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896704/
https://ncbi.nlm.nih.gov/pubmed/31806024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0857-5
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