Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, altered APP processing itself disrupts axonal transport. The mecha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Mórotz, Gábor M., Glennon, Elizabeth B., Greig, Jenny, Lau, Dawn H. W., Bhembre, Nishita, Mattedi, Francesca, Muschalik, Nadine, Noble, Wendy, Vagnoni, Alessio, Miller, Christopher C. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896704/
https://ncbi.nlm.nih.gov/pubmed/31806024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0857-5
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge