LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here we show that LMTK2 also interacts with kinesi...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Mórotz, Gábor M., Glennon, Elizabeth B., Gomez-Suaga, Patricia, Lau, Dawn H. W., Robinson, Eleanor D., Sedlák, Éva, Vagnoni, Alessio, Noble, Wendy, Miller, Christopher C. J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505310/
https://ncbi.nlm.nih.gov/pubmed/31068217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0715-5
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