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Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production
Understanding the mechanisms that control processing of the amyloid precursor protein (APP) to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. Here, we show that siRNA-mediated loss of calsyntenin-1 in cultured neurons alters APP processing to increase prod...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373235/ https://ncbi.nlm.nih.gov/pubmed/22434822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds109 |
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