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NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2

BACKGROUND: The dysfunction of type I interferon (IFN) signaling is an important mechanism of immune escape and metastasis in tumors. Increased NOS1 expression has been detected in melanoma, which correlated with dysfunctional IFN signaling and poor response to immunotherapy, but the specific mechan...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Xu, Pengfei, Ye, Shuangyan, Li, Keyi, Huang, Mengqiu, Wang, Qianli, Zeng, Sisi, Chen, Xi, Gao, Wenwen, Chen, Jianping, Zhang, Qianbing, Zhong, Zhuo, Lin, Ying, Rong, Zhili, Xu, Yang, Hao, Bingtao, Peng, Anghui, Ouyang, Manzhao, Liu, Qiuzhen
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896289/
https://ncbi.nlm.nih.gov/pubmed/31805977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1448-9
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