NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2

BACKGROUND: The dysfunction of type I interferon (IFN) signaling is an important mechanism of immune escape and metastasis in tumors. Increased NOS1 expression has been detected in melanoma, which correlated with dysfunctional IFN signaling and poor response to immunotherapy, but the specific mechan...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Xu, Pengfei, Ye, Shuangyan, Li, Keyi, Huang, Mengqiu, Wang, Qianli, Zeng, Sisi, Chen, Xi, Gao, Wenwen, Chen, Jianping, Zhang, Qianbing, Zhong, Zhuo, Lin, Ying, Rong, Zhili, Xu, Yang, Hao, Bingtao, Peng, Anghui, Ouyang, Manzhao, Liu, Qiuzhen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896289/
https://ncbi.nlm.nih.gov/pubmed/31805977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1448-9
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