The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism

Tempol (4-hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, TPL), a nitroxide compound, inhibits proliferation and increases the vulnerability of cancer cells to apoptosis induced by cytotoxic agents. However, the molecular mechanism of TPL inhibiting cancer cell proliferation has not been fully underst...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Ye, Shuangyan, Xu, Pengfei, Huang, Mengqiu, Chen, Xi, Zeng, Sisi, Wang, Qianli, Chen, Jianping, Li, Keyi, Gao, Wenwen, Liu, Ruiyuan, Liu, Jingxian, Shao, Yihao, Zhang, Hui, Xu, Yang, Zhang, Qianbing, Zhong, Zhuo, Wei, Zibo, Wang, Jiale, Hao, Bingtao, Huang, Wenhua, Liu, Qiuzhen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198543/
https://ncbi.nlm.nih.gov/pubmed/32366855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2499-8
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