The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism

Tempol (4-hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, TPL), a nitroxide compound, inhibits proliferation and increases the vulnerability of cancer cells to apoptosis induced by cytotoxic agents. However, the molecular mechanism of TPL inhibiting cancer cell proliferation has not been fully underst...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Ye, Shuangyan, Xu, Pengfei, Huang, Mengqiu, Chen, Xi, Zeng, Sisi, Wang, Qianli, Chen, Jianping, Li, Keyi, Gao, Wenwen, Liu, Ruiyuan, Liu, Jingxian, Shao, Yihao, Zhang, Hui, Xu, Yang, Zhang, Qianbing, Zhong, Zhuo, Wei, Zibo, Wang, Jiale, Hao, Bingtao, Huang, Wenhua, Liu, Qiuzhen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198543/
https://ncbi.nlm.nih.gov/pubmed/32366855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2499-8
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