Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones

Treatment of castration-resistant prostate cancer (CRPC) remains challenging due to the development of drug resistance. The Warburg effect describes the ability of cancer cells to consume larger amounts of glucose compared to normal tissues. We identified derivatives of natural 1,4-naphthoquinones t...

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Pubblicato in:Cancers (Basel)
Autori principali: Dyshlovoy, Sergey A., Pelageev, Dmitry N., Hauschild, Jessica, Borisova, Ksenia L., Kaune, Moritz, Krisp, Christoph, Venz, Simone, Sabutskii, Yurii E., Khmelevskaya, Ekaterina A., Busenbender, Tobias, Denisenko, Vladimir A., Pokhilo, Natalia D., Atopkina, Lyubov N., Graefen, Markus, Schlüter, Hartmut, Stonik, Valentin A., Bokemeyer, Carsten, Anufriev, Victor Ph., von Amsberg, Gunhild
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896172/
https://ncbi.nlm.nih.gov/pubmed/31671612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111690
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