Histone Demethylase KDM4C Stimulates the Proliferation of Prostate Cancer Cells via Activation of AKT and c-Myc

Our three-dimensional organotypic culture revealed that human histone demethylase (KDM) 4C, a histone lysine demethylase, hindered the acini morphogenesis of RWPE-1 prostate cells, suggesting its potential oncogenic role. Knockdown (KD) of KDM4C suppressed cell proliferation, soft agar colony format...

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Publicat a:Cancers (Basel)
Autors principals: Lin, Ching-Yu, Wang, Bi-Juan, Chen, Bo-Chih, Tseng, Jen-Chih, Jiang, Shih Sheng, Tsai, Kelvin K., Shen, Ying-Ying, Yuh, Chiou Hwa, Sie, Zong-Lin, Wang, Wen-Ching, Kung, Hsing-Jien, Chuu, Chih-Pin
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896035/
https://ncbi.nlm.nih.gov/pubmed/31766290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111785
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