Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

Targeted treatments for advanced gastric cancer (GC) are needed, particularly for HER2-negative GC, which represents the majority of cases (80 to 88%). In this study, in silico analyses of the lysine histone demethylases (KDMs) involved in diverse biological processes and diseases revealed that PHD...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Tseng, Lin-Lu, Cheng, Hsin-Hung, Yeh, Ta-Sen, Huang, Shih-Chiang, Syu, Ya-Yun, Chuu, Chih-Pin, Yuh, Chiou-Hwa, Kung, Hsing-Jien, Wang, Wen-Ching
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547212/
https://ncbi.nlm.nih.gov/pubmed/32958674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919766117
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