WWOX Possesses N-Terminal Cell Surface-Exposed Epitopes WWOX(7-21) and WWOX(7-11) for Signaling Cancer Growth Suppression and Prevention In Vivo

Membrane hyaluronidase Hyal-2 supports cancer cell growth. Inhibition of Hyal-2 by specific antibody against Hyal-2 or pY216-Hyal-2 leads to cancer growth suppression and prevention in vivo. By immunoelectron microscopy, tumor suppressor WWOX is shown to be anchored, in part, in the cell membrane by...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Wang, Wan-Jen, Ho, Pei-Chuan, Nagarajan, Ganesan, Chen, Yu-An, Kuo, Hsiang-Ling, Subhan, Dudekula, Su, Wan-Pei, Chang, Jean-Yun, Lu, Chen-Yu, Chang, Katarina T., Lin, Sing-Ru, Lee, Ming-Hui, Chang, Nan-Shan
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895976/
https://ncbi.nlm.nih.gov/pubmed/31752354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111818
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