A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

BACKGROUND: Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell migration, anchorage-independent growth, SMAD promot...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Chou, Pei-Yi, Lin, Sing-Ru, Lee, Ming-Hui, Schultz, Lori, Sze, Chun-I, Chang, Nan-Shan
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637503/
https://ncbi.nlm.nih.gov/pubmed/31315632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0382-y
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