Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Src Homology 2 (SH2) domains arose within metazoan signaling pathways and are involved in protein regulation of multiple pleiotropic cascades. In signal transducer and activator of transcription (STAT) proteins, SH2 domain interactions are critical for molecular activation and nuclear accumulation o...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: de Araujo, Elvin D., Orlova, Anna, Neubauer, Heidi A., Bajusz, Dávid, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Keserű, György M., Moriggl, Richard, Gunning, Patrick T.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895964/
https://ncbi.nlm.nih.gov/pubmed/31717342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111757
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