The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control spontaneous electrical activity in heart and brain. Binding of cAMP to the cyclic nucleotide-binding domain (CNBD) facilitates channel opening by relieving a tonic inhibition exerted by the CNBD. Despite high resolution struc...

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Veröffentlicht in:eLife
Hauptverfasser: Porro, Alessandro, Saponaro, Andrea, Gasparri, Federica, Bauer, Daniel, Gross, Christine, Pisoni, Matteo, Abbandonato, Gerardo, Hamacher, Kay, Santoro, Bina, Thiel, Gerhard, Moroni, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Structural Biology and Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894927/
https://ncbi.nlm.nih.gov/pubmed/31769408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49672
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