Data-driven construction of anti-tumor agents with controlled polypharmacology

Controlling which particular members of a large protein family are targeted by a drug is key to achieving a desired therapeutic response. In this study, we report a rational data-driven strategy for achieving restricted polypharmacology in the design of anti-tumor agents selectively targeting the TY...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Da, Chenxiao, Zhang, Dehui, Stashko, Michael, Vasileiadi, Eleana, Parker, Rebecca, Minson, Katherine A., Huey, Madeline G., Huelse, Justus M., Hunter, Debra, Gilbert, Thomas S. K., Norris-Drouin, Jacqueline, Miley, Michael, Herring, Laura E., Graves, Lee M., DeRyckere, Deborah, Earp, H. Shelton, Graham, Douglas, Frye, Stephen V., Wang, Xiaodong, Kireev, Dmitri
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894422/
https://ncbi.nlm.nih.gov/pubmed/31497954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08660
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