Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

BACKGROUND: We recently demonstrated an endolysosomal accumulation of the β-secretase-derived APP C-terminal fragment (CTF) C99 in brains of Alzheimer disease (AD) mouse models. Moreover, we showed that the treatment with the γ-secretase inhibitor (D6) led to further increased endolysosomal APP-CTF...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Lauritzen, Inger, Bécot, Anaïs, Bourgeois, Alexandre, Pardossi-Piquard, Raphaëlle, Biferi, Maria-Grazia, Barkats, Martine, Checler, Fréderic
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894230/
https://ncbi.nlm.nih.gov/pubmed/31827783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0176-6
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