Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

פריטים דומים

• Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
  מאת: Checler, Frédéric, et al.
  יצא לאור: (2021)
• The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models
  מאת: Bécot, Anaïs, et al.
  יצא לאור: (2020)
• Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
  מאת: Lauritzen, Inger, et al.
  יצא לאור: (2016)
• The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse
  מאת: Lauritzen, Inger, et al.
  יצא לאור: (2013)
• The β-Secretase-Derived C-Terminal Fragment of βAPP, C99, But Not Aβ, Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus
  מאת: Lauritzen, Inger, et al.
  יצא לאור: (2012)