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Dual role of cofilin in APP trafficking and amyloid-β clearance
The accumulation of amyloid-β (Aβ) plays a pivotal early event in the pathogenesis of Alzheimer’s disease (AD). In the brain, neurons produce Aβ by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pathway, whereas microglia mediate Aβ clearance also via endocytic m...
Guardat en:
| Publicat a: | FASEB J |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Federation of American Societies for Experimental Biology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6894083/ https://ncbi.nlm.nih.gov/pubmed/31646885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901268R |
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