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Dual role of cofilin in APP trafficking and amyloid-β clearance
The accumulation of amyloid-β (Aβ) plays a pivotal early event in the pathogenesis of Alzheimer’s disease (AD). In the brain, neurons produce Aβ by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pathway, whereas microglia mediate Aβ clearance also via endocytic m...
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| Udgivet i: | FASEB J |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Federation of American Societies for Experimental Biology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6894083/ https://ncbi.nlm.nih.gov/pubmed/31646885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901268R |
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