Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. While the accumulation of Aβ is pivotal to the etiology of AD, both the microtubule-associated protein tau (MAPT) and the F-actin severing protein cofilin are necessary for the deleterious effe...

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Publicat a:Commun Biol
Autors principals: Woo, Jung-A. A., Liu, Tian, Fang, Cenxiao C., Cazzaro, Sara, Kee, Teresa, LePochat, Patrick, Yrigoin, Ksenia, Penn, Courtney, Zhao, Xingyu, Wang, Xinming, Liggett, Stephen B., Kang, David E.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430779/
https://ncbi.nlm.nih.gov/pubmed/30911686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0359-9
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