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Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia. While the accumulation of Aβ is pivotal to the etiology of AD, both the microtubule-associated protein tau (MAPT) and the F-actin severing protein cofilin are necessary for the deleterious effe...
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| 出版年: | Commun Biol |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430779/ https://ncbi.nlm.nih.gov/pubmed/30911686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0359-9 |
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