Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier

The cause of antiseizure drug (ASD) resistance in epilepsy is poorly understood. Here, we focus on the transporter P-glycoprotein (P-gp) that is partly responsible for limited ASD brain uptake, which is thought to contribute to ASD resistance. We previously demonstrated that cyclooxygenase-2 (COX-2)...

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Vydáno v:FASEB J
Hlavní autoři: Soldner, Emma L. B., Hartz, Anika M. S., Akanuma, Shin-Ichi, Pekcec, Anton, Doods, Henri, Kryscio, Richard J., Hosoya, Ken-Ichi, Bauer, Björn
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894061/
https://ncbi.nlm.nih.gov/pubmed/31638830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901460RR
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