BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema

INTRODUCTION: Brain swelling due to edema formation is a major cause of neurological deterioration and death in patients with large hemispheric infarction (LHI) and severe traumatic brain injury (TBI), especially contusion-TBI. Preclinical studies have shown that SUR1-TRPM4 channels play a critical...

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Vydáno v:Expert Opin Investig Drugs
Hlavní autoři: Pergakis, Melissa, Badjatia, Neeraj, Chaturvedi, Seemant, Cronin, Carolyn A., Kimberly, W. Taylor, Sheth, Kevin N., Simard, J. Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893098/
https://ncbi.nlm.nih.gov/pubmed/31623469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13543784.2019.1681967
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