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Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date

Glyburide (also known as glibenclamide) is a second-generation sulfonylurea drug that inhibits sulfonylurea receptor 1 (Sur1) at nanomolar concentrations. Long used to target K(ATP) (Sur1–Kir6.2) channels for the treatment of diabetes mellitus type 2, glyburide was recently repurposed to target Sur1...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: King, Zachary A, Sheth, Kevin N, Kimberly, W Taylor, Simard, J Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101021/
https://ncbi.nlm.nih.gov/pubmed/30147301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S150043
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