Neuropathological correlates of amyloid PET imaging in Down syndrome

Down syndrome (DS) results in an over-production of amyloid-β (Aβ) peptide associated with early onset of Alzheimer’s disease (AD). DS cases have Aβ deposits detectable histologically as young as 12–30 years of age, primarily in the form of diffuse plaques, the type of early amyloid pathology also s...

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Udgivet i:Dev Neurobiol
Main Authors: Abrahamson, Eric E., Head, Elizabeth, Lott, Ira T., Handen, Benjamin L., Mufson, Elliott J., Christian, Bradley T., Klunk, William E., Ikonomovic, Milos D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892598/
https://ncbi.nlm.nih.gov/pubmed/31379087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.22713
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